Is ascites caused by impaired hepatic inactivation of blood borne endogenous opioid peptides?
نویسندگان
چکیده
Methionine enkephalin and catecholamines were measured in carefully collected plasma samples from 25 patients with cirrhosis and ascites, and 25 with cirrhosis without ascites, 15 disease and 15 healthy controls. Methionine enkephalin was invariably raised in the ascites group, the median value being 4.6-6.9 times that of the other three groups. Similarly, in the ascites group, median noradrenaline was increased 2.5-4.2 and median adrenaline 1.8-2.5 times that of the other groups. Plasma methionine enkephalin is considerably raised in patients with cirrhotic ascites and has actions which could enable it to be an initiating factor of ascites formation.
منابع مشابه
Augmentation of the natriuretic response to atrial natriuretic factor in cirrhosis.
HEPATOLOGY Elsewhere 897 the present study, high enkephalin levels were restricted to patients with ascites. Finally, most other peptides and amines found in increased circulating levels in patients with advanced cirrhosis (e.g. insulin, renin, catechol-amines) have an enhanced release rate-and not an impaired hepatic inactivation-as the main cause of the increased plasma levels (5, 6). However...
متن کاملاپوئیدها(Opioids) و دستگاه گوارش
SUMMARY The term opioid was coined to refer in a generic sense to all drugs, natural and synthetic, with morphin - like actions. Three distinct families of peptides have been identified so far in gastrointestinal (GI) nervous system in mammalian. These peptides include : dynorphin, Met - enkephalin and leu - enkephalin . Results from studies about opioid which have been started 15 years ago ...
متن کاملEndogenous and environmental factors interactions that contribute to the development of ascites in broiler chickens: a review
The increasing susceptibility of broiler chickens to ascites syndrome has coincided with a continuing genetic and nutritional improvement in their feed efficiency and growth rate. Ascites is multifactorial and interactions between environmental and endogenous factors play a particularly important role. The selection of fast growing broilers for high feed efficiency, which is characterized by hy...
متن کاملX Chromosome Inactivation in Opioid Addicted Women
Introduction: X chromosome inactivation (XCI) is a process during which one of the two X chromosomes in female human is silenced leading to equal gene expression with males who have only one X chromosome. Here we have investigated XCI ratio in females with opioid addiction to see whether XCI skewness in women could be a risk factor for opioid addiction. Methods: 30 adult females meeting DS...
متن کاملEffects of endogenous and synthetic opioid peptides on neutrophil function in vitro.
BACKGROUND Opioid peptides released from immunocytes during inflammation and stress in critically ill patients are associated with an altered immune response. Moreover, concentrations of opioid peptides are increased in peripheral blood and at the sites of inflammatory reactions. METHODS Using flow cytometric assay of whole human blood, we investigated direct effects of endogenous and synthet...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Gut
دوره 29 9 شماره
صفحات -
تاریخ انتشار 1988